Cook Biotech, Inc.

Cook Medical Technologies LLC

Cook Incorporated

Mark W Bleyer

Umesh H Patel

F Joseph Obermiller

David Nigel Armstrong

Brian L Bates

Neal E Fearnot

Brian C Case

Thomas A Osborne

Ram H Paul, Jr

Michael C Hiles

Thomas G Kozma

Jeffrey A Miller

Christopher J Moran

Brain L Bates

David N Armstrong

Ram H Paul

Jeffrey Miller

Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

Quilted implantable graft

An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.

Implantable graft to close a fistula

Disclosed is a medical device () and more particularly, an implantable biomaterial. The biomaterial comprises a radiopaque () collagenous biomaterial ().

Radiopaque implantable collagenous biomaterial device

A medical device () including a collagenous biomaterial () for causing embolus and treating an aneurysm. The collagenous biomaterial () includes a small intestine submucosa () that is configured into various components () for causing a vascular occlusion or a packing aneurysm lumen.

Embolization device

A tissue graft product includes at least one collagen layer comprised of submucosa or renal capsule tissue having slits therein to provide a mesh pattern which in turn establishes a graft structure that is highly deformable. The slits and mesh pattern provide for improved characteristics when utilized as a tissue graft and in particular an external wound care. Preferred devices have multiple submucosa, renal capsule or other collagenous extracellular matrix layers, providing a substantial and lasting scaffold for tissue ingrowth during wound treatment.

Medical graft device with meshed structure

A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration. A flap disposed adjacent the opening is able to temporarily and substantially close the opening to contribute to the regulation of retrograde flow proceeding through the valve.

Prosthetic valve that permits retrograde flow

A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration.

Growing community of inventors

West Lafayette, IN, United States of America

Mark W Bleyer