Gammadelta Therapeutics Ltd

F-star Therapeutics, Inc.

Mark Uden

Mihriban Tuna

Oliver Nussbaumer

Natalie Mount

Shristi Bhandari

Samuel Florence

Louisa Mathias

Kalle Soderstrom

Joshua Freedman

Andrew Hutton

Shefali Bhumbra

Robert Good

Raj Jaysukhlal Mehta

The present invention relates to a method for the isolation of lymphocytes (in particular γδ T cells) from a non-haematopoietic tissue sample comprising the steps of culturing a non-haematopoietic tissue sample which is an intact biopsy obtained from a non-haematopoietic tissue in the presence of Interleukin-2 (IL-2) and Interleukin-15 (IL-15); and collecting a population of lymphocytes cultured from the non-haematopoietic tissue sample. Methods of subsequent expansion are provided, as well as populations of isolated cells obtained by the method and uses thereof.

Methods for isolating and expanding cells

The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor (TCR); and the Fc region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.

Multispecific anti-TCR delta variable 1 antibodies

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London, United Kingdom

Mark Uden