King's College London

Mark Trevor Mills

Alan D Borthwick

Sarkis Barret Kalindjian

Jane Theresa Brown

Jonathan Patrick Thomas Corcoran

Maria Beatriz De Castro Vasconcelos Goncalves

Alan David Borthwick

Jonathan Patrick Corcoran

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as 'BHBA compounds'), which, inter alia, are (selective) retinoic acid receptor beta (RAR&#x3b2;) (e.g., RAR&#x3b2;2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RAR&#x3b2; (e.g., RAR&#x3b2;2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RAR&#x3b2; (e.g., RAR&#x3b2;2), that are ameliorated by the activation of RAR&#x3b2; (e.g., RAR&#x3b2;2), etc., including, e.g., neurological injuries such as spinal cord injuries. 

Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RAR&#x3b2;) agonists

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as 'BHBA compounds'), which, inter alia, are (selective) retinoic acid receptor beta (RAR&#x3b2;) (e.g., RAR&#x3b2;2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RAR&#x3b2; (e.g., RARP&#x3b2;2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RAR&#x3b2; (e.g., RAR&#x3b2;2), that are ameliorated by the activation of RAR&#x3b2; (e.g., RAR&#x3b2;2), etc., including, e.g., neurological injuries such as spinal cord injuries. 

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Nottingham, United Kingdom

Mark Trevor Mills