Medtronic, Inc.

Medtronic Ablation Frontiers LLC

Other

Medtronic Cryocath LP

Measurement Specialties, Incorporated

Medtronics, Inc.

North Dakota State University

Rtd Company

Haïssaguerre, Michel

Mark T Stewart

David E Francischelli

James R Skarda

Steven J Fraasch

Catherine R Condie

Timothy G Laske

Brian T Howard

Rahul Mehra

Marshall L Sherman

James R Keogh

Paul T Rothstein

Randell Louis Werneth

Gonzalo Martinez

James B Hissong

Xiaoyi Min

Eduardo N Warman

Harry A Puryear

Timothy J Corvi

William J Flickinger

Mary M Morris

Alexander J Hill

Jordon D Honeck

Douglas H Gubbin

J Christopher Flaherty

Johnson E Goode

Michael Jay Ebert

Dan Wittenberger

Douglas A Hettrick

John R Liddicoat

Timothy R Ryan

Carol Elsa Eberhardt

Steven F Bolling

David S Schwartzman

Zhongping C Yang

Vinod Sharma

William W Malecki

James F Kelley

Steven Lawrence Waldhauser

Benjamin K Yaffe

Roderick E Briscoe

Christopher F Kelly

John Louis Sommer

Mark T Marshall

Matthew David Bonner

Vladimir Pavlovich Nikolski

Cynthia T Clague

Steven C Christian

Mark E Henschel

Brian Lee Dukart

Christopher P Olig

Damian A Jelich

Kenneth W Keeney

Trenton Jay Rehberger

Edward Di Domenico

Catherine E Taylor

Meleze Hocini

Michael T Lau

Qin Zhang

Jinback Hong

Jon Virgil Evans

Tom P Daigle

David J Kim

Christopher Plott

Mark Allen Benscoter

Jay L Kelley

Thomas Daigle

Jack D Lemmon

Kenneth E Cobian

Michael J Hobday

Daniel Charles Haeg

Tessy Kanayinkal

Patrick Cloutier

Brett S Bowman

James M Speckien

Adam Podbelski

Mark A Thompson

Andrew Olson

Peter David Bernier

Bret R Shoberg

Asha Shrinivas Nayak

Daniel Cheek

Lynn A Davenport

Sarah E Ahlberg

Chris M Coppin

David L Miller

Dale A Wahlstrom

Mark W Torrianni

David J S Kim

Alan Carlson

Scott W Davie

Christopher J Plott

Michael M Green

Alison Lutterman

Rany Huynh

Scott G Klimek

Eric Meyer

Bushan K Purushothaman

Jay A Erlebacher

Richard A Thompson, Ii

Hong S Shim

The present invention advantageously provides a molding device with conductive material for creating a catheter balloon with conductive elements, and methods and systems for manufacturing the catheter balloon with conductive elements. An exemplary method for coupling a plurality of conductive elements to an expandable element may include placing a first portion of a mold proximate a second portion of the mold to define a casting cavity. Conductive material may be deposited into the casting cavity. Polymeric material may be inserted into the casting cavity. The first portion of the mold may be secured to the second portion of the mold. The polymeric material may be expanded to place the polymeric material in contact with the conductive material.

Method for applying conductors to catheter based balloons

A method and pulsed field ablation (PFA) system configured to provide variable impedance paths for delivery of electric fields to patient tissue using a PFA catheter are disclosed. According to one aspect, a method includes determining a current for each of a plurality of circuit paths, each circuit path including two electrodes. Each current may be determined based at least in part on: a desired voltage between the two electrodes; a tissue impedance between the two electrodes; and a parasitic impedance associated with the circuit path. The method also includes determining at least one of an excitation voltage and an input resistance for each circuit path of the plurality of circuit paths based at least in part on the determined current for the circuit path, parasitic impedances associated with the circuit path and a tissue impedance between the two electrodes in the circuit path.

Variable impedance paths for delivery of electric fields

A method and system for mapping tissue and producing lesions for the treatment of cardiac arrhythmias in a non-thermal and optimal manner, minimizing the amount of energy required to selectively stun or ablate the target tissues. Energy may be delivered only at the moment(s) of best device position and proximity of an electrode to target tissue, and only during a time in the cardiac cycle determined to be optimal for reversible or irreversible effects. A method may include determining timing of the cardiac cycle and an optimal time within the cardiac cycle for energy delivery, evaluating proximity between at least one energy delivery electrode and the target tissue, and delivering pulsed field energy from the at least one energy delivery electrode to the target tissue when, during the optimal time for energy delivery, the at least one energy delivery electrode is in close proximity with the target tissue.

Timed energy delivery

A pulsed field ablation medical device. Among other things, the medical device includes processing circuitry in communication with an electrosurgical generator and a plurality of electrodes. In one example, the processing circuitry is configured to determine a desired lesion characteristic; determine a first waveform parameter based on the desired lesion characteristic; deliver, via the plurality of electrodes, a first pulsed field waveform of the plurality of pulsed field waveforms based on the first waveform parameter to ablate the area of tissue; measure a second lesion characteristic based on a result of delivering the first pulsed field waveform; determine a second waveform parameter based on the second lesion characteristic; deliver, via the plurality of electrodes, a second pulsed field waveform of the plurality of pulsed field waveforms based on the second waveform parameter to ablate the area of tissue.

Profile parameter selection algorithm for electroporation

A system and method for the safe delivery of treatment energy to a patient, which includes verification of system integrity before, during, or after the delivery of treatment energy and provides several mechanisms for rapid termination of the delivery of potentially harmful energy to the patient when a fault condition in the device and/or system is identified. The system may include an energy generator having processing circuitry to determine if there is a fault condition in the system and to automatically terminate a delivery of treatment energy when the processing circuitry determines there is a fault condition. The method may generally include performing a series of pre-checks, synchronizing a treatment energy delivery to the proper segment of the heart's depolarization pattern, configuring the system for treatment energy delivery, delivering the treatment energy, and performing post-treatment evaluation.

Methods of ensuring pulsed field ablation generator system electrical safety

A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 μs and 5 μs, an inter-pulse delay of at least 5 μs, and a pulse width of 5 μs.

Cardiac pulsed field ablation

A medical device including a catheter having a proximal portion and a distal portion. A plurality of electrodes is disposed along the distal portion, the plurality of electrodes including a first electrode pair having a first fixed polarity and a second electrode pair having a second fixed polarity different than the first fixed polarity. A first lumen extends through the distal portion, the first lumen includes a first conductor configured to connect to a first electrode of the first electrode pair and a second conductor configured to connect to a second electrode of the first electrode pair. A second lumen extends through the distal portion and separated from the first lumen, the second lumen includes a third conductor configured to connect to a first electrode of the second electrode pair and a fourth conductor configured to connect to a second electrode of the second electrode pair.

Safety default return path for electric field therapy

A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between Oμs and 5 μs, an inter-pulse delay of at least 5 μs, and a pulse width of 5 μs.

Devices, systems, and methods for more efficiently ablating tissue with pulsed field ablation energy while minimizing collateral injury to non-target tissue. In one embodiment, a system for ablating tissue at a treatment site comprises: an energy delivery device; and a control unit including: a source of impedance-modifying fluid in fluid communication with the energy delivery device; an energy generator in electrical communication with the energy delivery device, the energy generator being configured to transmit energy to the energy delivery device and the energy delivery device being configured to deliver energy to the treatment site; and processing circuitry configured to control delivery of the impedance-modifying fluid from the energy delivery device to the treatment site. In one embodiment, a method for ablating tissue comprises delivering an impedance-modifying fluid to a treatment site and delivering pulsed field ablation energy to the treatment site.

Focal pulsed field ablation devices and methods

The present invention relates to a method, device, and system for improved mapping and/or ablation of a tissue. The device may generally include an elongate body and a distal assembly affixed to the elongate body that includes a treatment electrode having a conductive mapping region and a selectively conductive ablation region that is conductive of high-frequency current and substantially non-conductive of low-frequency current. Alternatively, the device may generally include a treatment electrode having a conductive mapping or ablation region and a region that is coated with an electrically insulated but thermally conductive layer.

Electrophysiology catheter design

Systems and methods to confirm safe delivery of treatment energy to a patient by identifying a presence of a fault in an energy delivery pathway and identifying a location of the fault within the device. The system includes a processing unit configured to calculate blood impedances external to the device based on known impedance characteristics of the device, and then to calculate impedances within the device during energy delivery based on the calculated blood impedances. The processing unit prevents the delivery of energy in an energy delivery pathway that is determined to be compromised. The processing unit is also configured to compare times for two different frequencies to travel a predetermined distance, the difference in the times corresponding to a location of a fault within the energy delivery pathway.

Method of confirming safe delivery pathway to patient prior to energy delivery

A method of determining a pulsed field ablation waveform parameter for creating a desired lesion characteristic in cardiac tissue. The method of provides an electrosurgical generator configured to deliver electroporation pulses, the generator configured to: load predetermined waveform parameters (y); load predetermined modeling data (x); accept entry of a user inputted desired lesion characteristic (u); and determine at least one corresponding pulsed field ablation waveform parameter based on (u), (y); and (x).

Growing community of inventors

Lino Lakes, MN, United States of America

Mark T Stewart