Illumina Corporation

Life Technologies Corporation

Applied Biosystems, LLC

Applera Corporation

Arizona State University

Yale University

The Perkin-elmer Corporation

Pe Corporation (ny)

Applera Corporation Applied Biosystems Group

Mark T Reed

Bryan Crane

Patrick Leung

David Marran

Dale Buermann

Jon A Hoshizaki

Drew R Verkade

Erik Lewis Williamson

Albert L Carrillo

Earl M Zergiebel

David Louis Heiner

Michal Lebl

Ian A Harding

Mark F Oldham

Robert C Kain

Kevin S Bodner

Matthew William Hage

Kamil Salloum

Stephen E Moring

Jonathan Posner

Wolfgang Heimberg

Mark R Pratt

Jason Bryant

Alexander Triener

Andrea Sabot

Hon Siu Shin

Jew Kwee Ngui

Sandro David Klein

Stanley S Hong

Colin Lloyd Barnes

Kai Qin Lao

Michael Phillip Snyder

Mark Wang

Harold Philip Swerdlow

Adrian Fawcett

Eric Hans Vermaas

Jason Harris

John Bridgham

Hitten P Zaveri

Klaus Maisinger

Frederick G Erie

Willy K Wiyatno

Alexander Kindwall

Dennis D Spencer

James Frank Klemic

Jason H Halsey

Alfred P Madden

Hock Lai Khoo

Michael Aaron Schroeder

Nathan Kane

Ward Kevin Frye

Andrew James Carson

Heng Zhu

Rui Zheng

Lim Hi Tan

Yang Hooi Kee

Zheng (Derek) Xing

Joseph Jackson

Creighton Buie

Ui Leng Soh

Chiu Tai Andrew Wong

Bojan Obradovic

Douwe D Haga

Joseph Podhasky

Oliver Davidson

Jamsheed Ghadiri

Isabelle Rasolonjatovo

Joseph H Jackson

Ching Ong Lau

Gary Schroth

Alexander P Kindwall

Michael R Flatbush

Michael Mosseau

Eric Williamson

Saibal Banerjee

Kevin Benson

Sergey Etchin

Johnny Ho

Xavier Lee

Peter Lundberg

Chiara Rodighiero

Subra Sankar

Tony S Yan

Zheng Xing

Hou Siu Shin

Frederick Erie

Jonny Ho

Ning Sizto

A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

Systems, methods, and apparatuses to image a sample for biological or chemical analysis

The present invention provides devices comprising multimodal depth electrodes for real-time quantification of chemistry and electrophysiology of the body. The devices are useful in several applications, including monitoring primary and secondary brain injury. The multimodal depth electrodes electrically transduce signals from biological parameters of interest, including EEG, temperature, pressure, oxygen level, blood flow, and chemistry.

Multiplexed implantable sensor probe

A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.

Fluid interface to receive removable container

A system includes a pipetting system including a 3-axis gantry; a sled mechanism to select a magnetic comb from a set of magnetic combs; a fluorometer; and a set of receptacles to receive welled plates. A method for purifying nucleic acids includes applying a sample to a well of a multi-well plate, selecting a magnetic comb from a set of magnetic combs disposed on a gantry system, collecting magnetic beads using the magnetic comb, collecting nucleic acid using the magnetic beads, and eluting the nucleic acid from the beads.

System and method for polynucleotide purification

A sensor device includes a substrate having a die attached to the substrate. The die includes an array of sensors and an array of wells cooperatively disposed over the array of sensors. The array of wells is exposed by the substrate. The sensor device further includes a flow cell secured to the substrate and defining a flow space disposed over the die and accessible to the array of wells. The flow cell defines a plurality of separate volumes. Each separate volume of the plurality of separate volumes has an inlet and an outlet. The plurality of separate volumes are separated by dividers. The dividers cover a set of wells of the array of wells.

Devices incorporating multilane flow cell

A fluidic coupler to engage a plurality of flow cells of a sensor device includes a body and a plurality of fluidics interfaces formed in the body. Each fluidic interface of the plurality of fluidics interfaces includes an opening, a first port in fluid communication with the opening, a second port, and a third port in fluidic communication with the second port.

Systems and methods for providing fluidic access to a flow cell

In an example, a method for preparing a nucleotide solution includes flowing an aqueous solution from an initial solution storage of a sequencing instrument continuously through a container fluidically coupled to the sequencing instrument, the container comprising a nucleotide concentrate; and collecting the aqueous solution with nucleotide in a storage container.

System and method for preparation of nucleotide solutions

A sequencing system includes an automated sequencing instrument adapted to determine variant calls for one or more extracted polynucleotide samples with a performance of at least 98.5% raw read accuracy and a run time in a range of 5 hours to 14 hours to determine variant calls for 4 extracted polynucleotide samples using a targeted assay with one DNA pool per sample and an average amplicon size in a range of 100 to 120 bases.

System and method for sequencing

An apparatus includes a fluidic coupler including an opening. A first port is in fluid communication with the opening and is to interface with an inlet of a flow cell of a sensor device. A second port is to interface with an outlet of the flow cell of the sensor device. A third port is in fluidic communication with the second port. The apparatus further includes a mechanical assembly moveable between a first position and a second position. The fluidic coupler is secured to the flow cell of the sensor device in the first position. The fluidic coupler is disengaged from the flow cell of the sensor device in the second position.

Growing community of inventors

Menlo Park, CA, United States of America

Mark T Reed