Mesoscale Technologies, Llc.

Igen International, Inc.

Other

Mirari Biosciences, Inc.

Meso Scale Technology Llp

Igen, Inc.

Bioveris Corporation

Meso Sclae Technologies, Llc.

Mark T Martin

George B Sigal

Jacob N Wohlstadter

Alan B Fischer

James L Wilbur

Mark A Billadeau

Larry Helms

Jonathan K Leland

Liang-Hong Guo

Jon Leland

Pam Liang

Rodger G Smith

Liwen Dong

Eli N Glezer

Richard J Massey

Michael Tsionsky

David M Simpson

Svetlana Leytner

Ramin Darvari

Richard C Titmas

Michael J Darsley

Robert Hoch

Gary F Blackburn

Fabian Jameison

Satyanarayana Gudibande

Selen Altunata

Ming Lu

Andrew D Napper

John H Kenten

Richard O Williams

Reid W Von Borstel

Wonpyo Hong

Balreddy Kamireddy

Richard G Saul

Selen Stromgren

Jan M Casadei

Rick Saul

John Gerald McCafferty

David John Chiswell

Rosa I Sanchez

Kevin Fitzgerald

The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

Kits suitable for use in electrochemiluminescence methods and methods of effecting a specific-binding non-wash assay

Graphitic nanotubes, which include tubular fullerenes (commonly called 'buckytubes') and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

Graphitic nanotubes in luminescence assays

A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.

Methods and apparatus for improved luminescence assays using microparticles

Assay buffer, compositions containing the same, and methods of using the same

Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Multi-array, multi-specific electrochemiluminescence testing

Materials and methods are provided for producing patterned multi-array, multi-specific surfaces which are electronically excited for use in electrochemiluminescence based tests. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use in flat panel displays and multiply specific testing procedures.

The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain reaction.

Methods and compositions for directed microwave chemistry

The present invention concerns a novel means by which liquids can be moved or mixed. Microwaves strike and heat materials that are highly susceptible to microwave heating. The susceptible materials are on, within, or near materials that melt or change shape in response to temperature increases. Upon microwave irradiation, these materials change shape (e.g., shrink or melt), causing the movement of liquids. The invention is important in many microfluidics applications, especially in biomedical analysis, where it is valuable to be able to move small volumes of liquids (e.g., on a microarray chip).

Microwave microfluidics

The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.

Method and apparatus for improved luminescence assays using microparticles

Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.

Growing community of inventors

N. Bethesda, MD, United States of America

Mark T Martin