Pfizer Corporation

Mark T Jefferson

Walter D Celmer

Walter P Cullen

Riichiro Shibakawa

Charles E Moppett

Junsuke Tone

John B Routien

Liang H Huang

Hiroshi Maeda

Frank C Sciavolino

Junsuki Tone

Kozo Inoue

A new species of Nocardiopsis, designated Nocardiopsis atra Huang sp. nov. ATCC 31511, when aerobically propagated in an aqueous nutrient medium, produces nocardicin A in good yield.

Process for producing nocardicin A

A species of Actinoplanes, designated Actinoplanes deccanensis Parenti, Pagani and Beretta subsp. salmoneus Huang subsp. nov., ATCC 31355, when subjected to submerged aerobic fermentation, produces a new antibiotic complex. Methods for the recovery and purification of the antibiotic complex and some of the individual antibiotic components are described.

Antibiotics produced by species of actinoplanes

A new species of Nocardia, designated Nocardia argentinensis Huang sp. nov., when subjected to aerobic submerged fermentation, produces a mixture of new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.

Antibiotics produced by new species of nocardia

A new polycyclic ether antibiotic with anticoccidial, antimicrobial and growth promotant properties, its production by fermentation and methods for its recovery and purification are described.

Polycyclic ether antibiotic

A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotic produced by new species of dactylosporangium

Two new species of Streptosporangium, designated Streptosporangium koreanum Routien sp. nov. and Streptosporangium cinnabarinum Routien sp. nov., when subjected to submerged aerobic fermentation, produce the same two new antibiotics. Methods for the recovery and purification of these antibiotics, co-produced with minor antibiotics, are described and some of their antimicrobial properties are outlined.

Mixture of antibiotics produced by new species of streptosporangium

Disclosed is a new antibiotic, Compound 41,012, which is produced by the submerged aerobic fermentation of a new species of Actinoplanes designated Actinoplanes nipponensis sp. nov. Routien, ATCC 31145. Methods for the recovery and purification of Compound 41,012 are also described as are some of its antimicrobial properties.

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Waterford, CT, United States of America

Mark T Jefferson