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The University of Mississippi

Mark T Hamann

Mohamed Ikbal Ali

Rae Matsumoto

Abir El-Alfy

Angelo Boujos

Anna J Kochanowska

Khalid El-Sayed

Aleutianamine represents the first in a new class of pyrroloiminoquinone alkaloids possessing a highly strained multi-bridged ring system, discovered from()Samaai, Kelly & Gibbons, 2006 (class Demospongiae, order Poecilosclerida, family Latrunculiidae) recovered during a NOAA deep-water exploration of the Aleutian Islands. Aleutianamine exhibited potent and selective cytotoxicity toward solid tumor cell lines including pancreatic cancer (PANC-1) with an IC50 of 25 nM and colon cancer (H116) with IC50 of 1 &#x3bc;M. 

Synthetic novel pyrroloiminoquinone alkaloid and method of use

This present provides kaempferol-3-(2-E,3-Z-di-p-coumaroyl)-rhamnoside, kaempferol-3-(2-Z-3-E-di-p-coumaroyl)-rhamnoside, and kaempferol-3-(2,3-di-Z-p-coumaroyl)-rhamnoside compounds useful as a new class of anti-bacterial agents. These compounds are extracted from. These compounds were found to exhibit anti-bacterial activity against methicillin resistant(MRSA).

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The sponges were collected from a variety of locations in the Florida Keys and separated based on morphology and color. The samples were identified as three species, two of which are well known:(Esper, 1794) (order Verongida, family Aplysinidae) and(Hyatt, 1875) (order Dictyoceratida, family Thorectidae), and a third(Duchassaing & Michelotti, 1864), is less common and separated based on subtle differences of morphology and coloration, from the other two species. Several compounds were isolated and were evaluated in established animal models predictive of neurological related drug function, namely, the rodent FST and the chick anxiety-depression model.

Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter

A method of treating an infectious disease or condition in a subject in need of such treatment is disclosed. The method comprises administering to a subject an effective amount of a manzamine, manzamine derivative or analog or an optical isomer or racemate or tautomer thereof or a pharmaceutically acceptable salt thereof.

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University, MS, United States of America

Mark T Hamann