Receptos, Inc.

The Scripps Research Institute

Mark T Griffith

Esther Martinborough

Marcus F Boehm

Premji Meghani

Liming Huang

Manisha Moorjani

Junko Tamiya

Andrew Richard Novak

Thomas Fowler

Michael Knaggs

Raymond C Stevens

Michael Allen Hanson

Wei Liu

Vadim Cherezov

Veli-Pekka Jaakola

Vsevolod Katritch

Aaron A Thompson

Joshua M Kunken

Fei Xu

Christopher B Roth

Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analysis of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.

GLP-1 receptor stabilizers and modulators

The invention provides the structure of human Aadenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.

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Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.

Growing community of inventors

San Diego, CA, United States of America

Mark T Griffith