Biovotion Ag

Mark Stuart Talary

Andreas Caduff

Hans-Joachim Krebs

Pavel Zakharov

Francois Dewarrat

Oscar De Feo

Gianluca Stalder

Daniel Huber

Alexander Megej

Gianlucca Stalder

Martin Müller

François Dewarrat

The apparatus for the non-invasive glucose detection comprises an electrical detection device () for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor () or alternative perfusion sensor (), improve the accuracy of the measured result.

Device for determining the glucose level in body tissue

A parameter affecting the absorptivity or the concentration of blood in tissue is measured using a semiconductor light source () and a light detector (). The semiconductor light source () is operated at several operating conditions, at which it has different temperatures and therefore different emission spectra. In particular, the operating conditions correspond to different time intervals after switching the light source () on, while the light source () has not yet reached thermal equilibrium. This allows to perform a spectroscopic measurement using one light source only, which increases accuracy and reduces device cost.

Optical determination of blood perfusion and similar parameters

Embodiments of the present invention comprise systems and methods for noninvasion measurements of physiological properties of tissues. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.

System for noninvasive optical measurements of physiological properties in tissue

A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

Wide band field response measurement for glucose determination

A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (), which carries a ground electrode () as well as a plurality of signal electrodes (-). The gaps () between the ground electrode and the signal electrodes are filled with a solid filler material () in order to provide an even surface. Optical reflection detectors () can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate () carries electronic high-frequency components for improving signal quality.

Sensing device for body tissue properties

A sensor device comprises a sensor () to be held against the wearer's skin. The sensor () is arranged on one side of a housing (), and the housing is connected to a band () for mounting it to a body part, such as an arm or leg. Various stopper devices () are arranged on the side of the housing () and the band () that face the skin. The stopper devices improve static friction, thereby holding the housing () in place.

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Zurich, Switzerland

Mark Stuart Talary