Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Merck Sharpe & Dohme Corp.

Mark Stuart Chambers

Sarah Christine Hobbs

Leslie Joseph Street

Victor Giulio Matassa

Angus Murray MacLeod

Tamara Ladduwahetty

Austin John Reeve

Sander G Mills

Malcolm MacCoss

Timothy Harrison

Raymond Baker

Jose Luis Castro Pineiro

Shrenik K Shah

Brian John Williams

Paul E Finke

Conrad P Dorn

Jeffrey John Hale

Francine Sternfeld

Howard Barff Broughton

Andrew Madin

Neil Roy Curtis

Graham A Showell

Kevin John Merchant

Michael Geoffrey Russell

Sylvie Bourrain

Alexander Richard Guiblin

Helen Jane Bryant

Richard Alexander Jelley

Angus Murray Macleod

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A, B, R2, R3 and q are as defined in the disclosure, pharmaceutical compositions containing them; methods for their production; their use in therapy and methods of treatment of disease states where cognition enhancement is required, such as Alzheimer's disease.

Substituted tetralone derivatives for enhancing cognition

The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof: ##STR1## where A is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, arylC.sub.1-6 alkyl, aryl, S(O),R.sup.1, OR.sup.1 or NR.sup.1 R.sup.6 ;

Substituted thienlycyclohexanone derivatives for enhancing cognition

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, arylC.sub.1-6 alkyl, aryl, S(O).sub.p R.sup.1, OR.sup.1 or NR.sup.1 R.sup.12 ;

Substituted thienobenzisoxazole derivatives for enhancing cognition

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

Morpholine and thiomorpholine tachykinin receptor antagonists

Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues

Substituted indolylpropyl-piperazine derivatives as 5-HT.sub.1D .alpha.

Piperidine and tetrahydropyridine derivatives

Substituted 1-indolylpropyl-4-benzylpiperazine derivatives

Indoline and azaindoline derivatives as 5-HT.sub.1D alpha receptor

Azetidine, pyrrolidine and piperidine derivatives

Substituted 1,4-piperazine-heteroaryl derivatives as 5-HT.sub.1D

Piperazine, piperidine and tetrahydropyridine derivative of

A class of substituted pyrrolo[2,3-c]pyridine derivatives are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

Pyrrolo-pyridine derivatives

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Puckeridge, United Kingdom

Mark Stuart Chambers