Bangor University

Diagnostig Ltd.

Universiteit Gent

Arcis Biotechnology Holdings Limited

Mark Stephen Baird

Christopher David Gwenin

Johan Adriaan Marc Grooten

Vanessa Valerie Gwenin

Juma'a Raheem Najeem Al Dulayymi

Gani Koza

Seppe Vander Beken

Alison Jones

Juma'a Raheem Najeem Al-Dulayymi

David Preskett

Cornelia Theunissen

Juma' A Raheem Najeem Al-Dulayymi

Seppe Vander-Beken

Cornelias Theunissen

Juma′ A Raheem Najeem Al-Dulayy-mi

Maximilliano Maza-Inglesias

Paul Anthony Fowler

Spencer Matthew Gould

Frank Arthur Howard

Radek Messias Braganca

Viacheslav Vitalievich Tverezovskiy

Mark Pitts

Salam Ghafour Taher

Mohsin Omar Mohammed

Joanne Louise Hacking

Juma'a Raheem Al Dulayymi

JUMA'A Raheem Najeem Al-Dulayymi

A method of determining whether an individual is infected with a mycobacterial disease, the method comprising: (a) providing a system which comprises an antigen; (b) contacting the system with a sample obtained from the individual; and (c) detecting the presence or absence of binding of a biomarker in the sample with the antigen; wherein the antigen is an arabinose ester of a mycolic acid or an analogue thereof.

Compositions and methods

A method of determining whether an individual is infected with mycobacteria. The method comprising the steps of (a) providing a system which comprises at least two different mycolic-acid derived antigens; (b) introducing a sample obtained from the individual into the system and into contact with each of the at least two different mycolic-acid derived antigens; and (c) detecting the presence or absence of the binding of a biomarker in the sample with each antigen in the system. The method may be particularly suitable for determining the presence or absence of a disease antibody indicative of infection with any disease caused by infection with mycobacteria, for example, leprosy, pulmonary disease, burili ulcer, Johne's disease and bovine. A kit and device are also described. The present invention may provide an over the counter device to allow individuals to check on a routine basis that they have normal immune responses.

Method and kit for detection of mycobacteria

A method of determining whether an individual is infected with a mycobacterial disease, the method comprising: (a) providing a system which comprises an antigen; (b) contacting the system with a sample obtained from the individual; and (c) detecting the presence or absence of binding of a biomarker in the sample with the antigen; wherein the antigen is a mycolic acid wax ester derived antigen.

A method of determining the presence or absence in a sample of a biomarker, the method comprising: (a) linking an antigen to colloidal gold to provide a gold-antigen species; (b) contacting the gold-antigen species with the sample; (c) adding a diagnosis agent to the sample; and (d) observing the color of the sample.

Method for determining the presence or absence of a biomarker

A method of determining the presence or absence in a sample of a biomarker indicative of exposure to mycobacteria, the method comprising: (a) providing a substrate carrying a mycolic acid derived antigen; (b) contacting the substrate with the sample; (c) contacting the substrate with a fluorophore species; (d) creating an evanescent wave at the boundary of the substrate and the sample; (e) detecting the presence or absence of fluorescence.

Method for determining exposure to mycobacteria

The present invention discloses a simple method for transforming cashew nut shell liquid into an active herbicidal composition.

Method for preparing a herbicidal compound

A method of preparing a compound of formula (III):(M)-(S)-(M')&#x2003;&#x2003;(III)wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M&#x2032; is independently a mycolic acid residue including a &#x3b2;-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each &#x3b2;-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.

Methods for pathogen detection and disease treatment

A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; Ris an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R, Rand Ris independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C&#x2014;OR; wherein Ris alkyl or haloalkyl, and A is O, S or NR, wherein Rmay be H or 20 alkyl. 

Compounds for use in therapy

A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; Ris an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R, Rand Ris independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C&#x2014;OR; wherein Ris alkyl or haloalkyl, and A is S, O or NR, wherein Rmaybe H or 20 alkyl. 

Adjuvants for use in vaccination

A method of obtaining a solid component rich in a petroselinic compound from the seed of a plant of the Apiaceae or Araliaceae families, the method comprising: (a) treating a portion of the seed of the plant with an extraction solvent; and (b) inducing formation of the solid component.

Method of obtaining a solid component rich in a petroselinic compound

Growing community of inventors

Gwynedd, United Kingdom

Mark Stephen Baird