Musculoskeletal Transplant Foundation

University of Southern California

Geistlich Pharma Ag

Mark Spilker

Eric Semler

Moon Hae Sunwoo

Lothar Schloesser

Yen-Chen Huang

Kevin Wu

Alison Ling

Evangelia Chnari

Joed Canales

Roman Shikhanovich

Morris Jacobs

Jeffrey Cartmell

Michelle Bubear

Amy Chang

Michele McAllister

David Wang

Charles Zelen

David Armstrong

Paul Glat

Jarrod Kaufman

Marco Mehr

Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.

Methods and compositions for preparing transplant tissue

Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.

Modified demineralized cortical bone fibers

A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.

Method for treating subjects suffering from chronic ulcers

Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.

Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.

Growing community of inventors

Kilchberg, Switzerland

Mark Spilker