Biora Therapeutics, Inc.

Hill-rom Services, Inc.

Cedars-sinai Medical Center

Progenity, Inc.

Baker Group, Llp

Biopreme Medical Technologies Inc.

Hill-rom Canado Respiratory Ltd.

Bt Bidco, Inc.

Mark Sasha Drlik

Mitchell Lawrence Jones

Nathan John Muller

Christopher Loren Wahl

Iman Niknia

Michael John Baker

Jeffrey A Shimizu

Nelson Quintana

Tuyen Nguyen

Christopher Ian Bunce

Stuart Robert Abercrombie

Nia Eleri Stevens

Nicholas Mark Salt

Edward Mudge

Ryan David Lee

Nicholas David Allan

Aaron Olafur Laurence Philippsen

Paul Charlebois

Kevin Howe

Nigel Anthony Syrotuck

Christian Terry Proch McMechan

Marten Jan DeVlieger

Ryan Elliott Jones

Pejman Rahimian

John David Russell

Sharat Singh

Mark Pimentel

Clive N Svendsen

Robert Stanford Magyar

Bjarne Hansen

Ali Rezaie

Kapil Gupta

Kenneth Maccallum

Doniel Drazin

Pablo Avalos

Alain Labbé

Shelby Suckow

Neil A Bhowmick

Sudeshna Dutta

Kristofor Dyck Dolberg

Martin Juergen Kellinghusen

Andrew Carlos Garland

Gene Alan Wey

Marten Jan DeVlleger

Marten Jan DeVliegar

Ryan Paul McGuinness

Alexsandr Kavokin

Ayon Bhowmick

Diptiman Choudhury

Alain Labbe

Clive Svendsen

Marten Jan Devlieger

Christian Terry Proch Mcmechan

Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.

Electromechanical pill device with localization capabilities

Systems and methods have been developed for implementation of a breath testing system for convenient sampling of intestinal gases exhaled from a patient's breath. This may include a system with a manifold that includes thermal regulation components, for instance thermistors and resistive heating elements, which maintain the temperature of the gases above the body temperature of the patient. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.

Breath gas analysis

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.

Ingestible device for delivery of a dispensable substance

A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

Methods and systems for a catheter access port cleaning, disinfection or sterilization device are disclosed. The catheter access port cleaning, disinfection or sterilization device may comprise, a first housing having a power source and control circuit; a second housing shaped to mate with a catheter and having a first ultra-violet light source mounted therein, the first housing wired to the second housing to power the light source. When activated, the ultra-violet light source emits ultra-violet radiation that is transmitted from the second housing to the catheter attached to a patient. In this way, the device provides an efficient system for cleaning, disinfecting or sterilizing an access port in the second housing while reducing patient infections.

Device and method for sterilizing a catheter system

The present invention teaches apparatuses, systems and methods for performing a variety of medical procedures, including those involving introducing one or more substances into a subject's body. In some embodiments, the invention teaches automatically performing guided injections into a tissue site (e.g. spinal cord) of a subject by using one or more electronically operated components including a cannula, a syringe pump, and a stereotactic device.

Apparatuses, systems and methods for controlled delivery of therapeutics and related substances

An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

A wearable thorax percussion device for dislodging mucous buildup in the airways of a human patient, the device comprising frame elements and electromechanical actuators retained by the frame elements to intermittently percuss the thorax, and an electronic controller and power source for generating and modulating an electrical signal to energize the actuator. The frame elements may be interconnected by a garment, or fasteners and elastic or adjustable strapping.

Method of making a wearable thorax percussion device

Modules, devices, systems and methods for measuring or detecting cysteine and/or methionine metabolite levels in a sample from a subject are disclosed. Various embodiments of the present invention concern modules, devices, systems and methods for prognosing or diagnosing cancer, for example, prostate, colon, ovarian or breast cancer; predicting the risk or probability of cancer recurrence; and/or for predicting, detecting and/or monitoring cystinuria or cystine stone disease.

Device, system and method for cancer prognosis and uses thereof

A negative pressure injection device which includes a suction cup and an inner skirt that encircles an injection port and depends into the interior of the suction cup. An injection member is surrounded by and protrudes below the inner skirt. When air is drawn from the suction cup an epidermis of a patient is drawn into the suction cup until the epidermis comes into contact with the inner skirt and that portion of the injection member protruding below the inner skirt. The inner skirt provides consistent epidermis positioning. The depth of injection is consistently defined by the extent to which the injection member protrudes below the inner skirt.

Negative pressure injection device

Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.

Sampling systems and related materials and methods

Wearable thorax percussion device

Growing community of inventors

Victoria, Canada

Mark Sasha Drlik