University of Southern California

California Institute of Technology

Second Sight Medical Products, Inc.

Doheny Eye Institute

Minipumps, LLC

The Johns Hopkins University

Neovista Inc.

Other

University of California

Alcon Pharmaceuticals Ltd.

Ut-battelle, Inc.

Lawrence Livermore National Security, LLC

Alcon, Inc.

Ico, Inc.

Iridex Corporation

Mark Salman Humayun

Yu-Chong Tai

Robert Jay Greenberg

Sean Caffey

James David Weiland

Matthew T McCormick

Ralph Kerns

Jason Shih

Charles DeBoer

Damien Craig Rodger

Fukang Jiang

Prashant Bhadri

James Singleton Little

Changlin Pang

Nicholas E Scianmarello

Matthew J McMahon

Po-Jui Chen

Jordan M Neysmith

Robert H Grubbs

Kelly Hobart McClure

Ashish Ahuja

Jeffrey David Brennan

Brian V Mech

Ellis Fan-chuin Meng

Alan Matthew Horsager

Lawrence Chong

Neil Hamilton Talbot

Arup Roy

Dao Min Zhou

David R Hinton

Ione Fine

Hossein Ameri

Richard A Hillstead

Charles E Larsen

Roelof Trip

Po-Ying Li

Eberhard Fritz

Rajat N Agrawal

Lincoln Vallance Johnson

Rainer Pintaske

Mark Edward Thompson

Raymond Peck

Bo Lu

Yi Zhang

Dennis O Clegg

Sherry T Hikita

Aaron Barnes

Rongqing Dai

Sumit Yadav

Terry Harrison Shelley

Armand R Tanguay, Jr

Aaron Christopher Barnes

Scott Greenwald

John J Whalen, Iii

Amy Hines

Geoffrey M Boynton

Dennis A Dougherty

Aubrey M Shapero

Eugene De Juan, Jr

Peter A Krulevitch

Da-Yu Chang

Neha J Parikh

Cedric Francois

Chunhong Zhou

Elias Stanley Greenbaum

Wolfgang Fink

Harry B Gray

Azita Emami

Julie K Hamilton

Mariam N Maghribi

Kevin Wilkin

Patrick Ryan

Choon Woo Lee

Stefan Ufer

Stan G Louie

Atoosa Lotfi

John Christopher Huculak

Jerry Ok

Kathleen Elizabeth Rodgers

Julian D Kavazov

Nicos A Petasis

Gere S DiZerega

Wendian Shi

Hyuck Choo

Jessy D Dorn

Francis S Markland, Jr

Choonsup Lee

Signe Erickson Varner

Lucien D Laude

William Andrew Brandt

Thomas George

Colin A Cook

Xuanhong Cheng

Patrick S Jensen

Didier Sagan

Devyani Nanduri

Andrew Dunn

Qifa Zhou

Dongyang Kang

An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.

Liquid accommodating intraocular lens with an asymmetric chamber

A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Method of manufacturing a tear flow measurement device

The disclosure herein provides methods, systems, and devices for a sterile ophthalmic surgical drape system that can provide a sterile operating field for use by a doctor, surgeon, nurse, and the like during ophthalmic medical procedures. The sterile field created by the drape system can allow a doctor, surgeon, nurse and the like to perform a medical procedure, such as ophthalmic surgery, outside of an operating room and in locations such as a doctor's office or a military operating room war setting. The sterile ophthalmic surgical drape system can comprise a drape, a frame apparatus, a hole of sufficient size for a microscope, a fan, a filter, air directors, and slits. The drape system can comprise a collapsible frame apparatus. The drape system may be configured to be used in conjunction with a surgical tray that houses pre-sterilized tools for use in a medical procedure.

Sterile surgical drape for ophthalmic surgery

A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

Contact lens with metered liquid system

A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Miniature fixed and adjustable flow restrictor for the body

In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Implantable continuous-flow pumps

Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

Cryopreservation of cell-seeded substrates and related methods

Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Polymer substrate retinal patch coated with adhesives

Tear flow measurement device

Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate

A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.

Instruments and methods for the implantation of cell-seeded ultra-thin substrates

The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

System for sutureless closure of scleral perforations and other ocular tissue discontinuities

Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 &#x3bc;m to 5 &#x3bc;m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

Ultrathin parylene-C semipermeable membranes for biomedical applications

Growing community of inventors

Glendale, CA, United States of America

Mark Salman Humayun