The University of Texas System

Medimmune Limited

Mark S Hanson

William R Jacobs, Jr

Charles K Stover

Eric J Hansen

Leslie D Cope

Gregory P Jarosik

Graham Hatfull

Shirley L Haun

Disclosed are hxuB and hxuC genes and DNA segments from H. influenzae such as H. influenzae type b (Hib) and nontypeable H. influenzae (NTHI). The HxuB and HxuC proteins, being surface expressed, are contemplated for use in the preparation of vaccines against pathological H. influenzae infections, and in particular, vaccines for use in children and other individuals who respond poorly to capsular-based vaccines. DNA segments encoding these proteins and anti- HxuB and HxuC antibodies will also be of in various screening, diagnostic and therapeutic applications.

H. influenzae HxuB and HxuC genes, proteins and methods of use

A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.

Vectors and prokaryotes which autocatalytically delete antibiotic

Growing community of inventors

Columbia, MD, United States of America

Mark S Hanson