Molecular Bioquest, Inc.

Omniquest Ltd.

Bioquest, Inc.

Binax Nh, Inc.

Mark S Chagnon

John R Ferris

Michelle J Carter

Tracy J Hamilton

Barry L Fiore

Edwin A Rudd

Kristin L Marzloff

Deborah A Kaplan

John Havelick, Jr

Maria A Gray

Tracy Hamilton

Stephen E Burkle

Inorganic oxides of substantially uniform particle size distribution are prepared by contacting aqueous solutions of an inorganic salt and an inorganic base across a porous membrane wherein the membrane contains a plurality of pores which allows for precipitation of a substantially mono-disbursed size inorganic oxide particles on one side of the membrane and precipitation of a salt of the corresponding base on a second side of the membrane.

Preparation of sub 100 A magnetic particles and magnetic molecular

Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid)--poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.

Preparation and use of novel injectable RES avoiding inorganic particles

This invention describes an electromagnetic wave-absorbing surface modified magnetic particle for use in medical applications. The magnetic particles are coated with an amphipathic organic compound and an amphipathic vesicle forming lipid. These particles may be used in a method of treatment of cancer, as well as for the treatment of infectious disease. For cancer treatment the invention comprises providing a patient said coated particles, absorbing the coated particle intracellularly into the cancer cell, and subjecting the patient to an alternating electromagnetic field to inductively heat the magnetic core particle along with the cancer cells. The inductive heating of the magnetic core particle is then continued so as to achieve an increase in intracellular temperature which selectively kills the cancer cells.

Electromagnetic wave absorbing, surface modified magnetic particles for

A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.

Solid care therapeutic compositions and methods for making same

Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

Biodegradable magnetic microclusters and methods for making them

Biodegradable magnetic microcluster comprising non-magnetic metal or

Electrically-conductive superparamagnetic liquid colloids and methods for making and using them are described. The magnetic liquid colloids contain magnetic particles coated with conductive, organio-metallic compund, which impart the magnetic and conductive characteristics to the fluid. The coated magnetic particles are dispersed in a carrier fluid that gives the fluid viscosity, flow and vapor pressure properties.

Superparamagnetic liquid colloids

A novel method for producing magnetic microparticles from metallocenes is disclosed. The method involves combining an aqueous slurry of the metallocene and an aqueous slurry of a metal hydroxide and milling the slurries together. Fine magnetic particles are produced using the present method.

Method for producing magnetic microparticles from metallocenes

Magnetic inks useful for the production of magnetic recording products are disclosed. The present magnetic inks contain ferromagnetic barium ferrite particles dispersed in a flexible polymer medium.

Growing community of inventors

Pelham, NH, United States of America

Mark S Chagnon