Janssen Biotech, Inc.

Mark Richter

Leonid Beigelman

James Patrick Edwards

Peter J Connolly

Guangyi Wang

Stuart Emanuel

Gilles C Bignan

Santhosh Kumar Thatikonda

Minghong Zhong

Marcel Viellevoye

Tianbao Lu

Sylvie Laquerre

Johannes Wilhelmus John Fitzgerald Thuring

Wim Schepens

Wim Bert Griet Schepens

Johannes Wilhelmus J F Thuring

Sylvia Laquerre

Wim Gert Griet Schepens

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R, R', X, B, R, R&#x2032;, B, X, R, Z-M-Y, and Y-M-Zare as defined herein. 

Cyclic dinucleotides as sting agonists

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, R, R, B, W, X, Y, Z are defined herein.

Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R, R, B, R, and Rare defined herein.

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:  wherein R, R, R, and Rare defined herein.

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Wayne, PA, United States of America

Mark Richter