Astrazeneca Ab

Mark Richard Ebden

Premji Meghani

Stephen Connolly

Anthony Ronald Cook

Craig Robert Stewart

Iain Alastair Stewart Walters

Andrew John Williams

Thomas Langer

Alan Robert Steven

Paula Margaret Tomlin

Roger Victor Bonnert

Colin Bennion

Simon David Guile

John Steele

Lal Lashkar Singh Cheema

Antony Ronald Cook

Iain Alastair Walters

There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound.  The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.

Compound

A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis, psoriasis or cancer. 

Pyrimidyl sulphone amide derivatives as chemokine receptor modulators

The invention provides compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy, wherein R, R, Rand n are as defined in the specification 

Compounds 679

Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic or prophylactic) of conditions/diseases in human and non-human animals which are exacerbated or caused by excessive or unregulated production of chemokines. 

Pyrimidine derivatives as modulators of chemokine receptor activity

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Cheshire, United Kingdom

Mark Richard Ebden