Wyeth

Zeneca Limited

Mark R Schmitt

Waldemar F Pfrengle

Guido Albert

Donald R Kirsch

Jane E Harris

Carl F Beyer

Klaus-Jüergen Pees

Paul A Carter

Sarjit S Johal

Christina L Hartman

The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

Substituted-triazolopyrimidines as anticancer agents

This invention pertains to methods for using oxalate oxidase in plant pathology. A substantially pure gene encoding the oxalate oxidase enzyme is elucidated. The expression product of the gene which can be stably incorporated into a foreign plant host has a unique profile including a pH optimum of 3.5, a positive heat stability, a single sub-unit of approximately 25 kilodaltons and protease stability. The methodology of this invention exploiting oxalate oxidase for protection against oxalic acid encompasses providing to a plant in need of oxalic acid protection an oxalic acid degrading enzyme in an amount sufficient to protect the plant from the oxalic acid.

Newly characterized oxalate and uses therefor

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Trenton, NJ, United States of America

Mark R Schmitt