Personalis, Inc.

Illumina Corporation

Applied Biosystems, LLC

Mark R Pratt

John West

Richard Chen

Gabor T Bartha

Sarah Garcia

Gemma Chandratillake

Hugo Yu Kor Lam

Shujun Luo

Helmy A Eltoukhy

Robert C Kain

Wenyi Feng

Poorya Sabounchi

Bernard Hirschbein

Jason Harris

Ming Chu Li

Tarun Kumar Khurana

Jason Bryant

Stanley S Hong

Bojan Obradovic

M Shane Bowen

Dale Buermann

Mark T Reed

Dietrich A Dehlinger

Danilo Condello

Alex Nemiroski

Yinghua Sun

Anthony Lam

Aaron Liu

Colin Lloyd Barnes

Mark Wang

Erik Lewis Williamson

Frederick G Erie

Marco A Krumbuegel

Harold Philip Swerdlow

David J Holden

Drew R Verkade

Eric Hans Vermaas

Bryan Crane

Patrick Leung

John Bridgham

Klaus Maisinger

Alexander Kindwall

Andrew James Carson

Isabelle Rasolonjatovo

Gary Schroth

Alexander P Kindwall

Xavier Lee

Subra Sankar

Chiara Rodighiero

Peter Lundberg

Johnny Ho

Sergey Etchin

Kevin Benson

Saibal Banerjee

Eric Williamson

Frederick Erie

Jonny Ho

Ning Sizto

This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Methods and systems for genetic analysis

A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer. A method is providing including obtaining signal data from an array of light detectors; determining a crosstalk function for each of the light detectors of the array of light detectors; and determining characteristics of analytes of interest based on the signal data using the crosstalk functions.

Biosensors for biological or chemical analysis and systems and methods for same

A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.

Illumination for fluorescence imaging using objective lens

A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

Methods and systems for genomic analysis

A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.

Growing community of inventors

Roseburg, OR, United States of America

Mark R Pratt