Other

I2 Technologies Us, Inc.

Blue Yonder Group, Inc.

Jda Software Group, Inc.

Mark R Miller

Xiaoling Li

Mamoun M Alhamadsheh

William K Chan

Sravan C Penchala

Miki S Park

Jian Yang

Vijay Krishnan Ganesan

Gayle Lynne Hayes

Jack V Miller

Ronald L Lawrence

Gayle Lynee Hayes

James W Godfrey

Vijay Krishnam Ganesan

Coleman C Arnett

Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Generating an optimized supplier allocation plan

The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Enhanced SN-38 anticancer agent

Enhanced anticancer agent

Delivering enhanced active agents

The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Enhanced active agents

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Systems for stabilizing and delivering active agents

Generalizing an optimized supplier allocation plan

A dual liquid spraying assembly comprises an outer container containing at least two separate compartments for two different liquids, a spray pump dispenser for mounting on the outlet of the container, and a valve assembly mounted between the compartments and the spray pump dispenser for controlling the proportions of the different liquids dispensed. The valve assembly comprises an inner valve member having a discharge outlet for connection to the spray pump dispenser and at least two inlets for connection to the respective compartments, and an outer, control sleeve rotatably mounted on the inner valve member for controlling connection of the inlets to the outlet. Both the inner and outer valve members are releasably secured on the outlet of the container to extend co-axially with the outlet opening.

Dual liquid spraying assembly

An apparatus is disclosed which creates a signal that indicates when a door has remained open for a predetermined amount of time. The apparatus includes a switch element responsive to the opening of the door and the closing of the door for monitoring the positional status of the door. The apparatus further includes electrical circuit components responsive to the monitoring switch for detecting when the door has been open for the predetermined period of time. The apparatus also includes electrical circuit components responsive to the detecting components for generating the signal indicating that the door has been open for the predetermined period of time.

Door status detector apparatus

A simulated vehicle radar transceiver is molded as a single, unitary piece of plastic material in the form of an elongated body having a large end which simulates the visual appearance of a vehicle radar antenna, a smaller end, and a horizontal projection which is adapted to be clamped between the top edge of an automobile window and the top of the respective window frame.

Simulated vehicle radar transceiver

Growing community of inventors

Stockton, CA, United States of America

Mark R Miller