The General Hospital Corporation

Northwestern University

The University of North Carolina at Chapel Hill

Mark R Karver

Ralph Weissleder

Scott A Hilderbrand

Neal K Devaraj

Samuel I Stupp

Melina R Kibbe

Miranda So

Mazen Albaghdadi

Nick D Tsihlis

Erica B Peters

Neel Anand Mansukhani

Provided herein are peptide amphiphiles (PAs). In some embodiments, provided herein are targeting PAs comprising a PA backbone and a targeting moiety. In some embodiments, provided herein are therapeutic PAs comprising a PA backbone and a therapeutic agent. In some embodiments, the peptide amphiphiles are co-assembled into nanofibers. In some embodiments, the nanofibers may be used for the treatment of atherosclerosis or related disease.

Drug delivery vehicles for atherosclerosis nanomedicine

The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a 'payload' to a ligand bound to a biological target.

Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions

Growing community of inventors

Chicago, IL, United States of America

Mark R Karver