Fuisz Technologies Ltd.

Biovail Laboratories International S.r.l.

Mark R Herman

Garry L Myers

Robert K Yang

Richard C Fuisz

Steven E Frisbee

Whitney S Cavanagh

Pradeepkumar P Sanghvi

John R Sisak

Joseph Cascone

Barbara Montwill

Bernard M Kiernan

John Getz

Nils Ahlgren

Desiree Pereira

Andrea S Brothers

Patrick B Woodall

Djelila Mezaache

Ed O'Donnell

Naima Mezaache

Joan Fitzpatrick

The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

Quick dissolve compositions and tablets based thereon

The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.

Fatty ester combinations

The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.

Method of preparing a dosage unit by direct tableting and product

A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.

Recipient-dosage delivery system

The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.

Liquiflash particles and method of making same

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Nokesville, VA, United States of America

Mark R Herman