Zoetis Services LLC

Mark R Cox

Richard Andrew Ewin

Tomasz Respondek

Todd M Maddux

Paul D Johnson

Rajendran Vairagoundar

Graham M Kyne

Timothy Lee Stuk

Imelda Hot

Timothy L Stuk

Susan M K Sheehan

Matthew W Bedore

Susan MK Sheehan

Defined herein are immunomodulating Formula (1) compounds stereoisomers thereof, and pharmaceutically acceptable salts thereof; wherein R, R, R, R, W, Ring C and n are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating o-het/aryl azalides

Defined herein are immunomodulating Formula (1) compounds, wherein R, R, R, R and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R,

Immunomodulating urea azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

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Kalamazoo, MI, United States of America

Mark R Cox