Aminex Therapeutics, Inc.

Mark R Burns

Nand Baindur

Kyle W Burns

Gerard F Graminski

Disclosed herein are pharmaceutical salts of a cationic protonated polyamine pharmaceutical agent and an anionic organic carboxylate which is hydrophobic when in protonated form, particularly suited for oral administration, where these salts have good bioavailability in solid dosage forms and may be used in the treatment of cancer and other medical conditions for which the pharmaceutical agent is intended.

Bioavailable poly amines

The invention relates to covers for wastewater treatment lagoons, which are typically covered by expansive stretches of sheet-form, high density polyethylene (HDPE). The invention more particularly relates to improvements in attaching HDPE patches at distributed locations thereon, which patches provide locally increased thickness to the cover in service as seats for attachment of further attachments to the cover, such as for example and without limitation HDPE straps for retention of HDPE grout-filled ballast pipes, and so on.

HDPE covers for wastewater treatment lagoons, and HDPE patches thereon in service for further attachments

Provided herein are combinations comprising difluoromethylornithine (DFMO), or an ionic form thereof, and a compound of the following structural formula: or a protonated form thereof, wherein values for the variables (e.g., a, b, c, d, e, n, R, R, X) are described herein. The combinations can provide combination drug therapy in a single pharmaceutical dosage form, and be used, for example, for the treatment of cancer.

Combination drug substance of polyamine transport inhibitor and DFMO

Bioavailable polyamines

The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.

Growing community of inventors

Epsom, NH, United States of America

Mark R Burns