University of Kansas

Mark Patrick Farrell

Cory Berkland

Suresh Eknath Kurhade

Fei Philip Gao

Jack Douglas Weiner

Patrick Andrew Ross

Kyle Apley

The present disclosure provides conjugates, methods of making the same, and uses thereof. The conjugates of the present technology are useful in inducing anergy in insulin-binding B cells.

Conjugates with inhibitory receptor ligands to induce anergy in insulin-binding B cells

The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where Ris an unsubstituted C-Calkyl; and R, R, and Rare each independently H or —C(O)—(unsubstituted C-Calkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.

Kifunensine derivatives

Growing community of inventors

Lawrence, KS, United States of America

Mark Patrick Farrell