Vaccinex, Inc.

Mark Paris

Ernest S Smith

Renee A Kirk

Angelica A Cornelison

Maurice Zauderer

Maria G M Scrivens

Leslie A Croy

Ekaterina Klimatcheva

Tracy Pandina

Angelica Moksa

Leslie A Balch

Maria Scrivens

Angelika Moksa

Compositions and method are provided for treating diseases associated with semaphorin-4D (SEMA4D) pathology, including autoimmune diseases, inflammatory diseases, cancers, neuroinflammatory disorders and neurodegenerative diseases.

Human anti-semaphorin 4D antibody

Compositions and methods are provided for treating diseases associated with CXCL13 expression, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CXCL13 monoclonal antibodies have been developed to neutralize CXCL13.

Anti-CXCL13 antibodies and methods of using the same

This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation for use in the screening, selecting, and identifying of antibodies or antibody-like molecules that bind to a target IMP of interest.

Integral membrane protein display on poxvirus extracellular enveloped virions

Polynucleotides encoding anti-CXCL13 antibodies

The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunit

Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus

Method for selecting polynucleotides encoding antigen-specific immunoglobulin subunits

Provided are monoclonal antibodies and antigen binding fragments thereof that specifically bind vascular endothelial growth factor (VEGF). The anti-VEGF monoclonal antibodies block VEGF binding to its receptors (e.g., VEGFR1 and/or VEGFR2) and prevent phosphorylation of VEGFR2 by VEGF. Also provided are methods of using the monoclonal anti-VEGF antibodies for treatment of disease, including cancer.

Anti-VEGF antibodies and uses thereof

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Mendon, NY, United States of America

Mark Paris