University of Utah Research Foundation

University of Rochester

Mark Noble

Mahendra S Rao

Margot Mayer-Proschel

John Elfar

Kuang-Ching Tseng

Walaa Elfar

Li Yue

Heather Natola

Christoph Proschel

John C Elfar

Christoph Pröschel

Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Composition and methods for the treatment of peripheral nerve injury

This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.

Erythropoietin for gastrointestinal dysfunction

A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5E-NCAMglial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5process-bearing astrocytes, and A2B5fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Lineage restricted glial precursors from the central nervous system

Methods using lineage restricted glial precursors from the central nervous system

A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5,E-NCAM,glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5,process-bearing astrocytes, and A2B5,fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

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Brighton, NY, United States of America

Mark Noble