Fluidigm Canada Inc.

University of Toronto

University Health Network

Standard Biotools Canada Inc.

Mark Nitz

Vladimir I Baranov

Xudong Lou

Mitchell Alan Winnik

David Hedley

Ravi N Vellanki

Landon J Edgar

Lisa M Willis

Matthew A Lumba

Hanuel Park

Bradly G Wouters

Mitchell A Winnik

Bradley G Wouters

A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.

Organotellurium compounds, compositions and methods of use thereof

Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).

Polymer backbone element tags

A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole. 

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Toronto, Canada

Mark Nitz