Massachusetts Institute of Technology

Dana-farber-cancer Institute Inc.

Mark Murakami

Scott R Manalis

Alexander K Shalek

Peter Winter

Jennyfer Galvez-Reyes

David Weinstock

Andrew Navia

Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject. In some embodiments, the methods can include determining an average cellular mass of cells in a sample from the subject and/or detecting one or more molecular signatures in one or more of the cells. In some embodiments, treatment includes administering one or more BCR-ABL tyrosine kinase inhibitors or a pharmaceutical formulation thereof, one or more pre-BCR signaling pathway inhibitors or a pharmaceutical formulation thereof, one or more p38 MAPK inhibitors or a pharmaceutical formulation thereof; or any combination thereof.

Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia

Growing community of inventors

Boston, MA, United States of America

Mark Murakami