Elysium Health, Inc.

Chromadex Inc.

Other

Mark Morris

Ryan Dellinger

Eric Marcotulli

Troy Rhonemus

Daniel Antonio Alminana

Dietrich Conze

Amy Boileau

Dan Alminana

Leonard Pershing Guarente

Santiago Roel Santos

Dolores Bishop

Marie Eugenie Migaud

Aron Erickson

Hadi Casser

Rajesh Thamatam

Infant formula compositions and methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Use of nicotinamide riboside, nicotinic acid riboside, and nicotinamide mononucleotide, reduced nicotinyl compounds, and nicotinoyl compound derivatives in infant formula for healthy development

Provided herein are methods and compositions related to treating and/or preventing liver related diseases and disorders and for improving liver health in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Nicotinamide riboside for use in treating or preventing liver damage

Provided herein are crystalline forms of nicotinamide riboside chloride and methods of making the same. Also provided are compositions comprising the crystalline form of nicotinamide riboside chloride, and therapeutic methods employing the crystalline form of nicotinamide riboside chloride.

Crystalline forms of nicotinamide riboside chloride

Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

Methods of synthesizing nicotinamide riboside

Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Provided herein are methods and compositions related to treating and/or preventing kidney related diseases and disorders, treating and/or preventing acute kidney injury, and for improving kidney health in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Treating and preventing kidney damage

Compositions are provided including nicotinic acid riboside ('NAR'), and derivatives thereof including 1-(2',3&#x2032;,5&#x2032;-triacetyl-beta-D-ribofuranosyl)-nicotinic acid ('NAR triacetate' or &#x201c;NARTA&#x201d;); or derivatives of a reduced form of nicotinic acid riboside (&#x201c;NARH&#x201d;), including 1-(2&#x2032;,3&#x2032;,5&#x2032;-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (&#x201c;NARH triacetate&#x201d; or &#x201c;NARH-TA&#x201d;); or derivatives of nicotinamide riboside (&#x201c;NR&#x201d;), including 1-(2&#x2032;,3&#x2032;,5&#x2032;-triacetyl-beta-D-ribofuranosyl)-nicotinamide (&#x201c;NR triacetate&#x201d; or &#x201c;NRTA&#x201d;); derivatives of a reduced form of nicotinamide riboside (&#x201c;NRH&#x201d;), including 1-(2&#x2032;,3&#x2032;,5&#x2032;-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinamide (&#x201c;NRH triacetate&#x201d; or &#x201c;NRH-TA&#x201d;); or salts or prodrugs thereof, for use in food or beverage applications, pharmaceutical formulations, or as a dietary supplement. Methods of using the compounds above to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (&#x201c;NAD+&#x201d;) or NADH in cells and tissues for improving cell and tissue survival or overall cell and tissue health are provided.

Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as NAD+ increasing precursors

A protective facial mask covering the oral and nasal cavities. It slips over the user's head and comprises a single generally cylindrical, generally tubular, piece of an expandable impervious material open at each end. Two diametrically opposed ear slots and an opening below and extending between the ear slots hold the mask in place and provide for better conformity to the user's head. A filtered breathing cannula on the interior of the mask allows air to enter the nasal cavity only.

Growing community of inventors

New York, NY, United States of America

Mark Morris