Comera Life Sciences, Inc.

Reform Biologics, LLC

Battelle Memorial Institute

Merrimack Pharmaceuticals, Inc.

Mark Moody

David S Soane

Robert P Mahoney

Philip Wuthrich

Rosa Casado Portilla

Daniel G Greene

Neil L Schauer

Ashwin Pasumarti

Joel Sminchak

Sam Shenghua Song

Arthur J Kudla

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.

Excipient compounds for biopolymer formulations

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.

Viscosity-reducing excipient compounds for protein formulations

Described herein is a method and techniques for subsurface monitoring. The system includes a downhole including a casting with a lumen, a wireless power transmitter within the casting, a micro-sensor cement mixture including a plurality of micro-sensors mixed with a cement, the micro-sensor cement mixture on a surface of the casting opposite from the lumen, a relay system including a plurality of relays, each of the plurality of relays including a charging component and a surface receiver. The wireless power transmitter configured to transmit a wireless power signal. At least one micro-sensor of the plurality of micro-sensors is configured to receive the wireless power signal, sense at least one attribute, and transmit a sensed signal. A series of relays are configured to receive the sensed signal and re-transmit the sensed signal and a surface receiver is configured to receive the sensed signal at a third time after the second time.

Wireless micro-sensors system for monitoring deep subsurface operations

Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.

Excipient compounds for protein processing

Methods and kits for detecting antibodies (e.g., anti-drug antibodies) specific for abundant body fluid components are provided. Such methods and kits permit the detection of, for example, human serum albumin in human body fluids, such as blood, plasma and serum.

Assays for anti-drug antibodies in the presence of abundant endogenous protein counterpart of the drug

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Concord, MA, United States of America

Mark Moody