Teva Pharmaceutical Industries Limited

Norton (Waterford) Limited

Teva UK Limited

Norton Gmbh

Mark Milton-Edwards

Michiel Ullmann

Lena Granovsky

Guilherme Safioti

Mark Steven Morrison

Enrique Calderon Oliveras

Douglas E Weitzel

James Roche

Frederic Scott Fleming

Michael Reich

Sven Dethlefs

Henry Chrystyn

Xinyu Liu

Amir Zur

Mark S Morrison

Provided is a system comprising an inhaler. The inhaler comprises a use determination system. The use determination system is configured to determine a parameter relating to airflow during a use of the inhaler by a subject. The use determination system also assigns a time to the use. The system also comprises a user interface, and a processing module. The processing module is configured to determine inhalation information from the parameter, and control the user interface to issue a notification that the inhalation information is available. The notification is issued at a notification time. The processing module is configured to implement a deliberate time delay such that the notification time is delayed relative to the time assigned to the use.

Inhaler system

Provided is a system for determining a probability of a respiratory disease exacerbation in a subject. The system comprises an inhaler arrangement for delivering a medicament to the subject. The medicament may be a rescue medicament and/or a maintenance medicament. The inhaler arrangement has a use-detection system configured to determine an inhalation performed by the subject using the inhaler arrangement. A sensor system is configured to measure a parameter relating to airflow during the inhalation. A user interface enables user-input of an indication of a status of the respiratory disease being experienced by the subject. A processor is configured to determine the probability of the respiratory disease exacerbation based on the recorded inhalation(s) from the use-detection system, the parameter(s) received from the sensor system, and the indication received from the user interface. Further provided is a method for determining the probability of a respiratory disease exacerbation in a subject.

Provided is a system () for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler () for delivering a rescue medicament to the subject. The inhaler has a use-detection system (B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor () configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.

An inhalation monitoring system includes an inhaler having a medicament delivery apparatus configured to deliver medicament to a user during an inhalation of the user; inhalation monitoring apparatus, configured to, during the inhalation, gather data for determining a measure of the user's lung function and/or lung health; and a processor configured to receive the data from the inhalation monitoring apparatus and, using the data, determine a measure of the user's lung function and/or lung health.

Inhalation monitoring system and method

A medicament-free device (e.g., a smartphone device) for simulating a medicament dispenser may include a sensing device and a processor. The sensing device may sense a user action performed upon the medicament-free device and may output sense data. The processor may receive the sense data, compare the sense data with predefined data, and provide feedback based on how the sense data compares to the predefined data. The predefined data may be indicative of a model user action associated with the medicament dispenser.

Training in dispensing a medicament

Inhaler

Respiratory apparatus

Growing community of inventors

Castleford, United Kingdom

Mark Milton-Edwards