Smithkline Beecham Corporation

Mark Mellinger

Joseph Marian Fortunak

Patrick L Burk

Joseph Sisko

Conrad John Kowalski

Jeffery L Wood

Antonietta Rose Mastrocola

Jeffrey Lee Wood

This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (&minus;)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Method for the synthesis of quinoline derivatives

A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.

Process for the preparation of certain 9-substituted camptothecins

A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12 H)-diones, said method being graphically illustrated as follows: ##STR1##

Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]quinolinones

Growing community of inventors

Telford, PA, United States of America

Mark Mellinger