Igen International, Inc.

Bioveris Corporation

Mark M Richter

Allen J Bard

Michael Joseph Powell

Christopher M Belisle

Russel H Schmehl

This invention pertains to the general field of chemical and biological assays which employ electrochemiluminscence (ECL), also referred to as electrogenerated chemiluminescence. More particularly, the present invention pertains to certain classes of chemical moieties which strongly quench ECL, and the use of these ECL quenchers in combination with ECL labels, for example, in ECL assay methods which employ an ECL quencher and an ECL label. One class of such quenching moieties are those which comprise at least one benzene moiety. Sub-classes of such quenching moieties are those which comprise at least one phenol moiety, quinone moiety, benzene carboxylic acid, and/or benzene carboxylate moiety.

Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers

Electrochemiluminescent label compounds containing multimetallic centers separated by bridging ligands are described. An example of a multimetallic electrochemiluminescent label suitable for use in electrochemiluminescence (ECL) methods, &lsqb;(bpy) Ru&rsqb; (bphb) , demonstrates ECL efficiencies 2 to 3 times greater than those for Ru(bpy) in acetonitrile and aqueous media. Such multimetallic ECL compounds may be especially useful in the design of new labels for bioanalytical applications, such as immunoassays and DNA probes.

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Springfield, MO, United States of America

Mark M Richter