Miroculus Inc.

Mark Lewis

Mais Jehan Jebrail

Foteini Christodoulou

Eduardo Cervantes

Rohit Lal

Ana Eugenia Carvajal

Methods and apparatuses for sequencing by synthesis using mechanical compression. These methods and apparatuses may mechanically control microfluidic movement using a force applicator and an elastically deformable sheet.

Sequencing by synthesis using mechanical compression

Methods and apparatuses for mechanically controlling microfluidic movement using a force applicator and an elastically deformable sheet are described herein. These apparatuses may include a mechanical microfluidics actuator devices and a cartridge. A microfluidic droplet may be moved or displaced within an air gap of the cartridge by applying a compressive force locally and selectively reduce the gap width of the air gap near the microfluidic droplet causing the microfluidic droplet to move toward the reduced gap. Compressive forces may also be used to divide, join, mix or perform other operations on the microfluidic droplets.

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San Francisco, CA, United States of America

Mark Lewis