Other

Sri International

The United States Government As Represented by the Department of Veterans Affairs

Wayne State University

Oregon State University

Sanford-burnham Medical Research Institute

The Burnham Institute

Molecular Medicine Research Institute

Mark Leid

Ling Jong

Peter D Hobbs

Joseph A Fontana

Xiao-kun Zhang

Marcia L Dawson

Gitali Indra

Joseph Abecassis

Xiao-Kun Zhang

Arup Kumar Indra

Marcia Dawson

The present disclosure provides methods of diagnosing and staging squamous cell carcinomas, for instance head and neck (HNSCC), by detecting chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) expression. For example, it is demonstrated herein that expression of CTIP2 is increased in SCC relative to a corresponding normal sample. Also included are kits for detecting SCC, as well as methods for identifying CTIP2 inhibitors.

CTIP2 expression in squamous cell carcinoma

The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

Induction of apoptosis in cancer cells

The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

Growing community of inventors

Corvallis, OR, United States of America

Mark Leid