Travera, Inc.

Massachusetts Institute of Technology

Mark L Stevens

Selim Olcum

Robert J Kimmerling

David O Caplan

Rob Kimmerling

Scott R Manalis

Don M Boroson

Clifford Reid

Anthony Minnah

Madeleine Vacha

Nicholas L Calistri

In silico tools are used to determine possibly effective therapies for treating a patient's cancer based on patient, drug, and cancer information. Functional assays can be performed on living cancer cells from the patient to evaluate the possibly effective therapies along with subsequent genomic or other more destructive assays to provide additional information from a single sample. Drug, patient, cancer, and outcome information can be recorded and updated iteratively and analyzed using machine learning to identify correlations between various patient, cancer, and drug characteristics and expected outcomes and drug efficacies.

Identifying cancer therapies

The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

Cellular measurement, calibration, and classification

The present invention includes methods and systems for assessing a cellular response to a treatment modality, such as potential drug candidate, by comparing normalized single-cell measurements of cellular properties without the need of a calibration step.

Treatment response assessment using normalized single cell measurements

Methods of calibration are provided. A method comprises introducing a material with cell-like properties and a known mass into a sensor on a measurement instrument to generate a calibration reading and adjusting an output module of the measurement instrument until the measurement instrument calibrates to the known mass for the material.

Calibration of a functional biomarker instrument

Systems and methods for flowing particles, such as biological entities, in a fluidic channel(s) are generally provided. In some cases, the systems described herein are designed such that a single particle may be isolated from a plurality of particles and flowed into a fluidic channel (e.g., a microfluidic channel) and/or collected e.g., on fluidically isolated surfaces. For example, the single particle may be present in a plurality of particles of relatively high density and the single particle is flowed into a fluidic channel, such that it is separated from the plurality of particles. The particles may be spaced within a fluidic channel so that individual particles may be measured/observed over time. In certain embodiments, the particle may be a biological entity. Such article and methods may be useful, for example, for isolating single cells into individual wells of multi-well cell culture dishes (e.g., for single-cell analysis).

Systems, articles, and methods for flowing particles

A filter-based method of demodulating differentially encoded phase shift keyed (DPSK) optical signals, such as commonly used binary-DPSK (DBDPSK) and quadrature DPSK (DQPSK) signals, that can achieve optimal receiver sensitivity is described. This approach, which combines filtering and differential phase comparison, can reduce the complexity and cost of DPSK receivers by obviating delay-line interferometer-based demodulation. This can improve receiver stability and reduce size, weight, and power, while maintaining the ability to achieve optimal communications performance.

Filter-based DPSK communications system

Filter-based DPSK receiver

A variable-bit-rate communication system is described. The communication system includes a variable-bit-rate transmitter that generates digital data at a first or a second bit rate and a variable-bit-rate receiver that receives the digital data. The digital data comprises a sequence of signaling waveforms having a first or a second duty cycle, respectively, wherein each signaling waveform has the same shape.

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Pepperell, MA, United States of America

Mark L Stevens