Wyeth

Pfizer Corporation

Other

Genetics Institute, Inc.

American Home Products Corporation

Millennium Pharmaceuticals Limited

Genencor, Inc.

Mark L Stahl

William Stuart Somers

Debra D Pittman

James Reasoner Apgar

Gregory John Carven

Lidia Mosyak

Zong Sean Juo

Laura Lin

Kevin Delos Parris

Matthew Holsti

Susan Benard

Sunita R Hett

Reema Jasuja

Macy Jin

Amy Szepui Tam

Jasbir S Seehra

Richard Alan Stahl

John A Stahl

Guang-Yi Xu

Rajiv Chopra

Zhang Bao Xu

Kathryn W Underwood

Kristine Svenson

Edward R LaVallie

Eugenio Ferrari

Jonathan A Bard

Lori J Fitz

Eric Steven Manas

Dennis J Henner

Robert L Powers

Francis Sullivan

Xiaotian Zhong

Andrea M Olland

Stephane Olland

Thomas E McDonagh

Tania Shane

Divya Chaudhary

Justin Cohen

Tatos Akopian

Francis X Sullivan

James M Wilhelm

Karl Malakian

Julie Lee

Rita Greco

Wah-Tung Hum

Meggin L Taylor

Laura Long Lin

Andrea Dessen

Hsiang-Ai Yu

Brian Dwyer

Jin Hong

Mark Johnson

Eleonora Presman

Bethany Annis Freeman

Scott Wolfrom

The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

Tissue factor pathway inhibitor antibodies and uses thereof

The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.

Muteins of clotting factor VIII

Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed.

Use of birthing manure to screen for pathogenic infection in farmed animals

Efficient multiple stage screening method to eliminate pathogenic infection in farmed animal populations

This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.

Method for identifying or designing a candidate agent that interacts with LINGO-1 polypeptide using a LINGO-1 three-dimensional structure

This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.

Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE)

A three-dimensional structure of human protein kinase C theta (PKC&#x3b8;) can be used in methods of designing an agent that interacts with PKC&#x3b8;. The agent can be an inhibitor of PKC&#x3b8; activity.

Structure of protein kinase C theta

Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.

Methods for the design of estrogen receptor ligands

This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.

Methods for identifying agents that interact with MAP kinase activated protein kinase 2

This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.

Crystal structure of yqeJ and uses thereof

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure ofACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Crystals of an acyl carrier protein synthase/acyl carrier protein complex

This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.

Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex

Growing community of inventors

Arlington, MA, United States of America

Mark L Stahl