Pneumrx, Inc.

Cardiac Dimensions, Inc.

Cardiac Dimensions Pty. Ltd.

Keravision, Inc.

Cordis Corporation

Addition Technology, Inc.

Free Flow Medical, Inc.

Other

Genesis Technologies Limited

Nitinol Development Corporation

Osprey Medical, Inc.

Nitinal Development Corporation

Mark L Mathis

David G Reuter

Gregory D Nieminen

Leonard Kowalsky

Patrick Peichen Wu

Nathan Aronson

Cruz Beeson

David P Thompson

David Lehrberg

Thomas A Silvestrini

Jaime Vasquez

John Mathew Adams

Lucas S Gordon

Bryan E Loomas

Ryan H Braxtan

Clifton A Alferness

Michael P Boutillette

Thomas Duerig

Andrew Stein

Ronald Dieck

James M Davenport

Erin McGurk

Garrett R Beget

Timothy R Machold

John Anthony Scholl

Greg Nieminen

Robert A Proudfoot

Verna Rodriguez

William Richard Dubrul

Bruce S Addis

Luis A Davila

David F Yankelevitz

Clifford Dwyer

Amelia Lasser

Brent Seybold

Frederick Feller, Iii

David J Wilson

Richard Eustis Fulton

Jeffrey Wayne Etter

David Martin Kaye

Janet Burpee

John Melmouth Power

Phillip M Leopold

Clifford J Dwyer

Dieter Stoeckel

Alan Roy Pelton

Scott J Wolf

Clif Alferness

Philip M Leopold

Brian J Doll

Kara Andersen Reiter

Adam Lucas Bilney

Charles Wartchow

Scott Kaarto

Frederick Stewart

Michael W Lau

Kevin Mitz

David Thompson

Lucas Gordon

Erin Mcgurk

Nathan A Aronson

Dave P Thompson

Frederick Feller Iii

Brent D Seybold

Frederick Iii Feller

Richard E Fulton, Iii

Richard E Iii Fulton

Systems and methods involve abrading a patient lung airway wall to reduce mucus production therein. Exemplary techniques include rotationally and/or linearly oscillating an abrasive material against the airway wall so as to damage mucus producing tissues, for example by removing goblet cells, while destroying less than the entire airway wall. The abrasive material may be present on the surface of an expandable balloon body or another expandable device, which can be delivered to the patient treatment site via a bronchoscope. In some cases, the abrasion techniques can cause cell damage or death at a controlled or predetermined tissue depth.

Devices, methods, and systems to treat chronic bronchitis

An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

Device and method for modifying the shape of a body organ

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. A variety of embodiments are provided, including pulmonary treatment devices that move portions of lung tissue around a rotational axis into a torqued configuration, anchoring such tissue in place for improved breathing mechanics.

Devices, treatments and methods to restore tissue elastic recoil

Guidewires suitable for use in a system for implanting a lung volume reduction device are disclosed. The guidewire includes an outer sheath having proximal and distal ends, and comprising a proximal section, a transition section, and a distal section. The proximal section extends from the proximal end of the sheath to the transition section, and the distal section extends from the transition section to the distal end of the sheath. The distal section defines a bore extending from the transition section to the distal end of the sheath and an inner core having proximal and distal ends. The inner core extends through the bore of the distal section of the sheath, wherein the inner core is fixed to the sheath at the transition section, and wherein the distal end of the inner core is fixed to the distal end of the sheath at the distal end of the sheath.

Guidewire

A container for a medical device having a housing defining a cavity for receiving a device, such as a lung volume reduction coil, is disclosed. In some embodiments, the container includes a coupling zone external to the cavity, an exit aperture between the cavity and the coupling zone, and a bearing surface located within the cavity, the bearing surface, exit aperture and coupling zone defining an exit path along which the device can be moved for deployment from the container. The bearing surface is spaced from the exit aperture and arranged, together with the coupling zone, such that the exit path is substantially straight. In some embodiments, the cavity may be approximately cylindrical, and the bearing surface, the exit aperture, and the coupling zone are aligned such that the exit path extends in a direction that is substantially tangential to the cavity.

Containers for medical devices

A method for treating a genetically associated chronic obstructive pulmonary disease. At least one implant is advanced into an airway of a lung having a genetically associated chronic obstructive pulmonary disease. The at least one implant is delivered into the lung to increase tension of the lung and thereby improve breathing function of the lung.

Genetically-associated chronic obstructive pulmonary disease treatment

An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.

Tissue shaping device

The present invention generally provides improved medical devices, systems, and methods, particularly for treating one or both lungs of a patient with an implant, such as a coil, having a strength tuned to a patient's tissue treatment region. More particularly, embodiments of the present invention include a method for treating a lung of a patient with chronic obstructive pulmonary disease. The method comprises determining a regional tissue density of at least a portion of lung tissue of the patient and selecting between first and second coils based on the determined regional tissue density of the portion of lung tissue. In particular, the first coil has a first austenite final tuning and second coil has a second austenite final tuning different than the first tuning. Determining may comprise imaging at least the portion of lung tissue of the patient so as to identify a localized lung tissue density. Selecting may comprise matching the determined tissue density of the treatment region to a tuned strength of the first or second coil.

Tuned strength chronic obstructive pulmonary disease treatment

Devices for treating mitral valve regurgitation, including a distal expandable anchor, a proximal expandable anchor, and a fixed length connecting member extending from the proximal expandable anchor to the distal expandable anchor, where at least one of the proximal and distal anchors includes first and second arm segments that extend from one end of the device toward the connecting member and the other anchor when in a collapsed delivery configuration, and where the at least one of the proximal and distal anchors that comprises the first and second arm segments has an expanded configuration in which the first and second arm segments extend radially outwardly such that the first and second arm segments extend away from one another toward the connector, and meet one another at a location axially spaced from the end of the device.

A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Enhanced efficacy lung volume reduction devices, methods, and systems

The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

Lung volume reduction devices, methods, and systems

Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

Cross-sectional modification during deployment of an elongate lung volume reduction device

Growing community of inventors

Fremont, CA, United States of America

Mark L Mathis