Other

Creighton University

Genome Therapeutics Corporation

Oscient Pharmaceuticals Corporation

Mark L Johnson

Robert R Recker

Randall D Little

John P Carulli

Donald B Kimmel

Susan M Recker

Guodong Gong

The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

High bone mass gene of 11q13.3

High bone mass gene of 1.1q13.3

The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

The invention provides the chromosome location of an autosomal dominant gene associated with high bone mass. As a result of this localization, the presence of a polymorphism linked to the autosomal dominant gene in a subject can be detected by analyzing human chromosome 11 of the subject for the presence of the polymorphism located about 30 cM around D11S987 and linked to the autosomal dominant gene. The analysis of chromosome 11 can be accomplished by amplifying the polymorphism, separating the amplified polymorphism to generate a polymorphism pattern, and correlating the presence or absence of the polymorphism with the respective presence or absence of the autosomal dominant gene associated with high bone mass.

Genetic markers to detect high bone mass

A golf training device is provided that includes an attitude sensor, audible alarm, a power source, and associated electrical circuitry, all contained in a relatively small rotatable cylindrical enclosure. The device senses the orientation of the head of the golfer such that when the vertical axis of the golfer's head is coincident with a vertical orientation, a sensing device assumes a first state while otherwise the sensing device assumes a second state; A timing device is connected with the sensing device such that as long as the sensing device assumes the first state, the timing device is inactive, while when the sensing device assumes the second state, a timing period is initiated, continuing until the timing period is completed, unless the sensing device again assumes the first state before the completion of the timing period whereupon the timing device again is inactive until the next incident when the sensing device assumes the second state; An audible alarm is connected to the timing device, the alarm producing an alarm signal in response to the completion of the timing period; and the sensing device is mounted to move with the head of the golfer during the golf swing; whereby the timing period may be set such that minor movement of the head of the golfer which causes the vertical axis of the golfer's head to move out of the vertical orientation does not produce an alarm signal while a premature tilt of the head of the golfer greater than said minor movement during the golf swing will produce an alarm signal.

Training device for golfer

A cotton cart with a discharge control apparatus in the basket is provided. A tray-shaped member is mounted in the basket for movement between a retracted position and a discharge position. The member is supported by a system of links so that the member pivots about a moving pivot point. As a result, the leading edge of the member follows an eccentrically arced path which conforms substantially to the inner contour of the basket to facilitate evacuation of the basket. The member is operated by a hydraulic cylinder, thereby enabling the operator to manipulate the cotton bolls during the discharge procedure.

Growing community of inventors

Omaha, NE, United States of America

Mark L Johnson