Takeda San Diego, Inc.

Novartis Ag

H. Ernest Schnepf

George E. Schwab

Mark Knuth

Kenneth E. Narva

Michael R. Pollard

Guy Cardineau

Tracey Ellis Michaels

Bernhard Hubert Geierstanger

Glen Spraggon

Ciaran N Cronin

Robert A Wijnands

Robert J Skene

Bi Ching Sang

Duncan E McRee

Tetsuo Uno

Steven Lee Bender

Shailaja Kasibhatla

Scott Glaser

Leslie William Tari

John Trauger

Douglas R Dougan

Sarah Rue

Michael DiDonato

Nikola P Pavletich

Jacek Nowakowski

Shelly Meeusen

Hua Zou

Devon A Thompson

Anna Galkin

Sabine Rottmann

Tracy Charlton

Carolina Nicole Simpson

Tobias Junt

George E Schwab

Keith P Wilson

Ronald V Swanson

Sridhar Govinda Prasad

Clifford D Mol

David J Hosfield

Mark Hilgers

Gyorgy Snell

Ellen Chien

Kathleen Aertgeerts

Sheng Ye

Oleg Brodsky

Michelle L Kraus

Kheng Lim

Marc E Navre

Eric Adam

Darbi Witmer

H Ernest Schnepf

Michael R Pollard

This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Anti-CCR7 antibody drug conjugates

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.

Methods of treating immune related disorders using antibody-cytokine engrafted compositions

Antibody cytokine engrafted compositions and methods of use for immunoregulation

Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.

Crystallization of histone deacetylase 2

Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.

Crystallization of aurora/LPL1P-related kinase

Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.

Crystallization of MAPK/ERK Kinase 2

Provided are crystals relating to DPPIV and its various uses.

Crystallization of dipeptidyl peptidase IV (DPPIV)

Provided are crystals relating to Cathepsin S and its various uses.

Crystallization of cathepsin S

Provided are crystals relating to AKT3 and its various uses.

Crystallization of AKT3

Growing community of inventors

El Cajon, CA, United States of America

Mark Knuth