Novartis Ag

Mark Kagan

Mahavir Prashad

Yugang Liu

Sven Erik Godtfredsen

Zhaoyin Wang

Yongshuai Chai

Saijie Zhu

Sven Erik Godtfredson

Mahavar Prashad

The present disclosure provides a compound of Formula (I);  or a pharmaceutically acceptable salt thereof, wherein Rand Rare defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.

Substituted bisphenyl butanoic ester derivatives as NEP inhibitors

The present disclosure provides a compound of Formula (I); 

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East Hanover, NJ, United States of America

Mark Kagan