Evonik Degussa Gmbh

Mark K Williams

Oskar Zelder

Stefan Haefner

Corinna Klopprogge

R Rogers Yocum

Andrea Herold

Hartwig Schröder

Thomas A Patterson

Janice G Pero

Christoph Wittmann

Hartwig Schroder

Elmar Heinzle

Jens Kroemer

Theron Herman

The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a &#x394;metF organism or a &#x394;metE AmetH organism, for example, mutants ofor, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A &#x394;metF &#x394;metB strain ofcan use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.

Use of dimethyl disulfide for methionine production in microoraganisms

The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.

Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase

The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

Microorganism and process for the preparation of L-methionine

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Revere, MA, United States of America

Mark K Williams