G.d. Searle & Company

Pharmacia Corporation

Pfizer Corporation

Monsanto Company

G.d. Searle LLC

Covx Technologies Ireland Limited

Pharmacia Corporation (of Pfizer, Inc.)

Mark John Pozzo

Jon P Lawson

John S Ng

Bernhard Erb

Yuen-Lung L Sing

Leo J Letendre

Joseph J Wieczorek

Chin Liu

Edward E Yonan

Sastry A Kunda

Dennis K Anderson

Ping T Wang

Julio A Baez

Gennaro Mucciariello

Fortunato Vanzanella

Richard M Weier

Thomas R Kowar

Samuel J Tremont

Claire A Przybyla

Kevin J Koeller

James C Peterson

Payman N Farid

Kevin Babiak

Pierre-Jean Colson

Benxin Zhi

Robert Hett

Grace Mary Wagner

Jay S Trivedi

Lawrence M Miller

Vladislav Orlovski

Eduardo K Mar

Andrew Carpenter

Gerald A Weisenburger

Christian H Huber

Shine Chou

James J Li

Palani Balu

Mark Maloney

Rory Francis Finn

Haim Moskowitz

Jin Xie

Olivier Alexandre Laurent

Javier Magano

Durgesh Vasant Nadkarni

Moorthy Sitharamaiah Suriyanarayana Palanki

Nancy Jane Levin

Jie Huang

John Joseph Teixeira, Jr

James Li

Nicholas Gary Luksha

Gopinath Vedachalam Annathur

Joseph Patrick Martin, Jr

Olivier J Marcq

Gregory Allan Waszak

Mark Thomas Maloney

John Joseph Teixeira

The present invention provides a process for preparing a compound of Formula 5b, as well as intermediates thereof, and novel classes of compounds useful in process for preparing these and similar compounds. 

Processes for preparing peptide conjugates and linkers

The present invention provides a composition of the formula: [FGF21-1Linker]-[Ab]-[2-Linker-Ex4]; wherein FGF21 is an FGF21 homologue; and Ex4 is an Exendin4 homologue; and Ab is an aldolase catalytic antibody or antigen binding portion thereof; and the 1linker is covalently attached to the side chain of a protein-linking residue in FGF21 and to a combining site of the antibody, and the 2linker is covalently attached to the side chain of a peptide-linking residue in Ex4 and to a combining site of the antibody, and wherein the first and second linker are the same or different. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.

Anti-diabetic compounds

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.

Method for the preparation of tetrahydrobenzothiepines

Process for preparation of 9,11-epoxy steroids and intermediates useful therein

5&bgr;-cyano-substituted steroid compounds

A process for the formation of an epoxy compound comprising contacting a substrate compound having an olefinic double bond with a peroxide compound in the presence of a peroxide activator, said peroxide activator corresponding to the formula:

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

Keto-Substituted Steroid Compounds

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Chesterfield, MO, United States of America

Mark John Pozzo