Adv Antest Corporation

Vertex Pharmaceuticals, Inc.

Mark Jeffrey Sullivan

Mariusz Krawiec

Ales Medek

Praveen Mudunuri

Edward Earl King

Steven C Johnston

Sneha Ghanshyam Arekar

David A Heaps

Richard R McKay

Gregory Scott Self

A holder and apparatus for terahertz imaging and/or spectroscopy of beads, particles or microparticles, and methods for terahertz imaging and/or spectroscopy of beads, particles or microparticles and making the holder are disclosed. The holder includes a tray having a substantially planar upper surface, and one or more offsets above or below the substantially planar upper surface. Each offset is configured to hold one of the beads, particles or microparticles, and has a height or depth configured to minimize or eliminate interference between reflections of the terahertz radiation from the tray and reflections of the terahertz radiation from the bead, particle or microparticle in or on the offset.

Methods, sampling device and apparatus for terahertz imaging and spectroscopy of coated beads, particles and/or microparticles

A method of determining a density of a roller compacted ribbon is disclosed. The method comprises compacting dry pharmaceutical powder between press rollers of a roller compactor to produce a compact ribbon. The method also comprises determining a thickness at a point on the compact ribbon in a non-invasive manner after it has rolled out from in between the press rollers. Further, the method comprises passing the compact ribbon through a gap in between the terahertz emitter and the terahertz detector. Next, the method comprises determining a refractive index at the point on the compact ribbon using a measurement value from the terahertz emitter and the terahertz detector and a measured value for the thickness at the point. Finally, the method comprises computing a density of the compact ribbon at the point using a value of the refractive index.

Dynamic measurement of density using terahertz radiation with real-time thickness measurement for process control

The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

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Framingham, MA, United States of America

Mark Jeffrey Sullivan