Hoechst Marion Roussel

Guilford Pharmaceuticals, Inc.

Mark J Vaal

Michael L Edwards

Roger A Parker

Mark T Yates

Kim S Chen

Gregory S Hamilton

Joseph P Steiner

Paul S Wright

Steven J Busch

Ling Wei

James E Matt

Yong-Qian Wu

Sergei Belyakov

David Limburg

Douglas Wilkinson

James E Matt, Jr

Chi Choi

The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.

Non-peptidic cyclophilin binding compounds and their use

The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.

Trisubstituted carbocyclic cyclophilin binding compounds and their use

This invention relates to the compounds of 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)methyloxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxyphenylsilyl)methyloxy]phenol, polymorphs thereof and their pharmaceutically acceptable salts, useful as antiatherosclerotic agents.

2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 and R.sub.6 are each independently C.sub.1 -C.sub.6 alkyl;

Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

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Baltimore, MD, United States of America

Mark J Vaal