Hoffmann-la Roche Inc.

Hoechst Celanese Corporation

Mark J Sebastian

Rudolf Schmid

David L Coffen

Thomas M Leslie

Bernice I Feuer

A method of separating isomers of functionalized aromatic compounds using solvent-modified supercritical carbon dioxide is disclosed and claimed. In one embodiment, isomers of hydroxynaphthoic acid are separated by selective extraction of the more soluble species.

Supercritical separation of isomers of functional organic compounds at

This invention provides multistep process embodiments for the production of novel esters which exhibit nonlinear optical response. A process embodiment is illustrated by the reaction of a Schiff base with a substituted acetic acid to form a stilbene alcohol intermediate: ##STR1## The stilbene alcohol intermediate is decarboxylated, and then is esterified in the presence of a pyridine type catalyst to provide an ester with a conjugated structure.

Process for the production of esters exhibiting nonlinear optical

A process for producing natural vitamin E and intermediates in this process.

Lower-alkyl or aryl-sulfonyl unsaturated tacopherols

Vitamin E intermediate

Vitamin E intermediates

6-Etherified hydroxy -2-(4',8',12'-trimethyl-5'-tridecenyl)-2,5,7,8-tetramethylchromans with an oxo or hydroxy substituent at the 2' position which may be substituted with an arylsulfonyl or a carboxyalkyl at the 3' position and containing a single or double bond at the 11 position, said chromans being intermediates for producing natural vitamin E.

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Plainfield, NJ, United States of America

Mark J Sebastian