University of Minnesota

Mark J Osborn

Bruce Robert Blazar

Jakub Tolar

Daniel F Voytas

Beau R Webber

Keli Hippen

Bruce Blazer

The present disclosure provides modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells (e.g., modified Tregs) that are steroid and/or calcineurin inhibitor-resistant. The present disclosure provides methods for generating steroid and/or calcineurin inhibitor-resistant modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells. Also provided herein are compositions and methods of treatment.

Drug-resistant immune cells and methods of use thereof

The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

TALEN-based gene correction

Methods of gene correction, methods of generating induced pluripotent stem cells (iPSCs), and methods of deriving multi-lineage cell types with therapeutic value. In some embodiments, the gene correction affects the expression and/or function of the functional type VII collagen protein (C7).

Method for correcting a genetic sequence

Talen-based gene correction

Growing community of inventors

Saint Paul, MN, United States of America

Mark J Osborn